PPI co-therapy cuts risk of anticoagulant-related upper GI bleeds

Large US study also finds some NOACs increase risk of bleed more than others

The choice of anticoagulant and PPI co-therapy may affect the risk of upper gastrointestinal (GI) tract bleeding in elderly patients, according to a large retrospective US study.

The analysis includes more than 1.6 million patients (mean age of 76) with more than 1.7 million new episodes of oral anticoagulant treatment, 75% of which for atrial fibrillation.